Modafinil 200mg Australia, also known as Provigil, is a wakefulness promoting agent that helps to improve sleepiness and fatigue. It has been approve by the FDA for treating narcolepsy, obstructive sleep apnea/hypopnea syndrome and shift work disorder (SWD).
In large-scale double-blind placebo-controlled clinical trials, modafinil significantly improved both subjective and objective measures of sleepiness. These include improvements in sleep latency on the MSLT and the ability to remain awake on a MWT.
Symptoms
The benzyhydrylsulfinylacetamide drug modafinil (Provigil) is FDA approved to treat excessive sleepiness associated with narcolepsy, shift work sleep disorder (a condition that causes difficulty falling or staying asleep during scheduled sleeping hours when working night shifts), and obstructive sleep apnea/hypopnea syndrome (a sleep-related breathing problem in which the patient stops and starts breathing repeatedly throughout the night).
It belongs to the class of medications known as wakefulness promoting agents. Modafinil increases cortical catecholamine levels and indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels.
In studies that compared the effectiveness of modafinil to placebo, treatment with this medication significantly improved overall clinical conditions for excessive sleepiness. The mean change from baseline in the ESS score, which was the primary en point in these studies, was 71% better in patients treated with modafinil than in those who received placebo.
Although modafinil can help reduce EDS in narcolepsy, it does not cure the disorder, and individuals who are treated with this medication should still follow good sleep habits (such as sleeping in a dark room and avoiding caffeine close to bedtime) and take other steps to prevent excessive sleepiness, such as losing weight, exercising regularly, and following the other treatment recommendations for their condition.
Also, individuals who are taking this medication should avoid activities that require a high level of wakefulness until they know how well modafinil will work for them.
Diagnosis
Modafinil is in a class of medications call wakefulness promoting agents. It is use to treat excessive sleepiness caused by narcolepsy and shift work sleep disorder (sleepiness during scheduled waking hours in people who work night or rotating shifts). It is also sometimes use along with breathing devices or other treatments for obstructive sleep apnea/hypopnea syndrome (OSA/HAP) to improve wakefulness.
Across large-scale, double blind, placebo controlled studies, modafinil improved sleepiness in patients with narcolepsy and shift work disorder. It also improved sleepiness in patients with OSA/HAP who were receiving CPAP therapy. Specifically, modafinil significantly reduced MSLT sleep latency. Improved ability to remain awake on the MWT and reduced self-reported sleepiness in the Epworth Sleepiness Scale (ESS).
More recently, preclinical studies have shown that modafinil exerts a unique immunomodulatory effect by inhibiting immune cell infiltration into damaged brain regions, decreasing glial activation and neuroinflammation and attenuating neurodegeneration in animal models of neurodegenerative diseases.
While Modafinil can help you stay alert, it is not a cure for sleep disorders. You must use practical sleep strategies and seek medical advice to manage sleep problems that occur while you are taking this medication. For example, you should try to take your dose of this medication early in the day to minimize its impact on your nighttime sleep. You should also limit your intake of caffeine, other stimulants and alcohol, and practice relaxation techniques at bedtime.
Treatment
Modafinil is a wakefulness-promoting medication and has the same effects on the brain as a stimulant. However, it has lower liability to abuse and is less likely to affect organ systems, such as the cardiovascular system. This makes it a potential treatment for a variety of medical and psychiatric disorders that are currently treate with stimulants, including fatigue syndromes, narcolepsy, and treatment-resistant depression.
It is also being studied as a cognitive enhancer. It increases cortical catecholamines, upregulates cerebral serotonin, glutamate, and orexin, and decreases cerebrovascular gamma-aminobutryic acid (GABA) levels. The effects of this drug have been studie in healthy non-sleep-deprive individuals. But the results have been mixe and more research is need.
Excessive sleepiness
The medicine is available by prescription only and comes as a tablet to take by mouth. It is usually taken each morning to prevent excessive sleepiness in people with narcolepsy or 1 hour before work shifts in those with shift work sleep disorder. It is also used along with breathing devices or other treatments for obstructive sleep apnea/hypopnea syndrome (OSAHS).
Taking this medication may cause you to become more sensitive to sunlight. Use sunscreen and limit your exposure while you are on this medication. It can also make it harder for hormonal birth control to work. So talk with your doctor about using another method of birth control while you are taking this medication.
Side Effects
Modafinil, sold under the brand name Provigil, is an FDA-approved medication to promote wakefulness. It is use in patients with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder to counteract daytime sleepiness. It is also use off-prescription as a cognitive enhancement drug by students, soldiers. And shift workers due to its perceived ability to increase mental focus and alertness.
Modafinil is an eugeroic that directly increases cortical catecholamine levels and indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels.
In double-blind, placebo-controlled studies and long-term studies, modafinil significantly improved objectively determined wakefulness on the MWT and ability to stay awake, as well as reduced self-reported sleepiness on the ESS, and improved FOSQ scores for vigilance, general productivity, activity, and social outcome.
Dizziness or drowsiness
This medication may cause dizziness or drowsiness. Do not drive or use machinery until you know how it affects you. Avoid alcoholic beverages and marijuana (cannabis). This drug can interact with other medications, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all of your medicines, including those you take now and any that you start or stop using.
This medication should not be use by pregnant women or those who plan to become pregnant. It is not know whether it passes into breast milk. Consult your doctor before breastfeeding. Read More Blog…
